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BIOPHARMACEUTICALS for HUMAN HEALTH in TRANSGENIC PLANTS.

from - TRENDS in Plant Science Vol.6 No.5 {page 224} © - Elsevier Science 2001

The production of biopharmaceuticals for human health in transgenic plants
Key-
Potential application or indication - Plant host - Protein - Expression levels - TSP = total soluble protein.

Human proteins
Anticoagulant Tobacco Human protein C <0.01% TSP
Thrombin inhibitor
Canola ( Brassica napus) Human hirudin 0.30% seed protein
Neutropenia Tobacco Human granulocyte-macrophage colony-stimulating factor Not reported
Growth hormone Tobacco Human somatotropin, chloroplast 7.00% TSP
Growth hormone Tobacco Nuclear expression <0.01% TSP
Anemia Tobacco Human erythropoietin <0.01 TSP
Antihyperanalgesic by opiate activity Arabidopsis Human enkephalins 0.10% seed protein
Wound repair and control of cell proliferation Tobacco Human epidermal growth <0.01% TSP
Hepatitis C and B treatment Rice, turnip ( Brassica rapa) Human interferon-alpha Not reported
Hepatitis C and B treatment Tobacco Human interferon- beta <0.01% fresh weight
Liver cirrhosis, burns, surgery Tobacco Human serum albumin 0.02% TSP
Blood substitute Tobacco Human hemoglobin alpha, beta 0.05% seed protein
Collagen Tobacco Human homotrimeric collagen <0.01% fresh weight
Cystic fibrosis, liver disease and hemorrhage Rice Human alpha-1-antitrypsin Not reported
Trypsin inhibitor for transplantation surgery Maize Human aprotinin Not reported
Antimicrobial Potato Human lactoferrin 0.10% TSP

Non-human proteins
Hypertension
Tobacco, tomato Angiotensin-converting enzyme Not reported
HIV therapies
Nicotiana bethamiana alpha-Tricosanthin from TMV-U1 Subgenomic coat protein 2.00% TSP
Gaucher’s disease
Tobacco Glucocerebrosidase 1.00–10.00% TSP


Because of space limitation, reviews that cite original citations are not provided.

New - Patent Lists (with Overall Page Index).

Recombinant Proteins from Plants: Methods & Protocols - 2008. editors Loic Faye & Véronique Gomord - currently the best, most up to date book on Molecular Farming